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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRP6
All Species:
20
Human Site:
S1564
Identified Species:
40
UniProt:
O75581
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75581
NP_002327.2
1613
180443
S1564
T
S
D
L
N
Y
D
S
E
P
V
P
P
P
P
Chimpanzee
Pan troglodytes
XP_001152103
1613
180424
S1564
T
S
D
L
N
Y
D
S
E
P
V
P
P
P
P
Rhesus Macaque
Macaca mulatta
XP_001117791
1209
134638
K1161
E
G
C
G
V
L
P
K
V
R
L
L
L
V
S
Dog
Lupus familis
XP_534886
1613
180464
S1564
T
S
D
L
N
Y
D
S
E
P
V
P
P
P
P
Cat
Felis silvestris
Mouse
Mus musculus
O88572
1613
180236
S1564
T
S
D
V
N
Y
D
S
E
P
V
P
P
P
P
Rat
Rattus norvegicus
Q9QYP1
1905
211861
L1857
I
Q
A
S
S
G
S
L
D
D
T
E
T
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508455
1480
165692
E1432
S
D
L
N
Y
D
S
E
P
V
P
P
P
P
T
Chicken
Gallus gallus
XP_417286
1567
175502
E1519
S
D
L
N
Y
D
S
E
P
V
P
P
P
P
T
Frog
Xenopus laevis
NP_001079233
1613
180585
S1564
I
S
D
L
N
Y
D
S
E
P
V
P
P
P
P
Zebra Danio
Brachydanio rerio
NP_001128156
1620
180715
N1568
K
G
Y
A
S
D
L
N
Y
D
S
E
P
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P98163
1984
219502
T1863
A
E
A
G
V
G
F
T
T
E
T
G
T
V
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202408
1322
148003
Y1274
A
N
P
E
A
V
N
Y
D
S
E
P
Y
P
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
28.8
99.1
N.A.
97.8
28.3
N.A.
86.7
86.4
85.1
81.3
N.A.
20.1
N.A.
N.A.
42.2
Protein Similarity:
100
100
43.4
99.8
N.A.
99.3
45
N.A.
89.8
92
92.8
90.4
N.A.
36.1
N.A.
N.A.
56.5
P-Site Identity:
100
100
0
100
N.A.
93.3
0
N.A.
20
20
93.3
13.3
N.A.
0
N.A.
N.A.
20
P-Site Similarity:
100
100
6.6
100
N.A.
100
13.3
N.A.
26.6
26.6
93.3
26.6
N.A.
6.6
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
17
9
9
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
17
42
0
0
25
42
0
17
17
0
0
0
0
0
% D
% Glu:
9
9
0
9
0
0
0
17
42
9
9
17
0
9
0
% E
% Phe:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% F
% Gly:
0
17
0
17
0
17
0
0
0
0
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
9
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% K
% Leu:
0
0
17
34
0
9
9
9
0
0
9
9
9
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
17
42
0
9
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
9
0
0
0
9
0
17
42
17
67
67
67
59
% P
% Gln:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
9
% Q
% Arg:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% R
% Ser:
17
42
0
9
17
0
25
42
0
9
9
0
0
0
17
% S
% Thr:
34
0
0
0
0
0
0
9
9
0
17
0
17
0
17
% T
% Val:
0
0
0
9
17
9
0
0
9
17
42
0
0
17
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
17
42
0
9
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _